But well-conducted studies have led many doctors to conclude that the risks of MHT often outweigh the benefits. It does not discuss other possible risks of MHT such as heart disease or stroke. Menopause is sometimes called the change of life , or the change. The ovaries stop releasing eggs and making the female hormones, estrogen and progesterone. In the months or years leading up to natural menopause, menstrual periods may become less frequent and irregular, and hormone levels may go up and down.